Die Durchblutung der Niere weist gegenüber anderen Organen bedeutende Unterschiede auf. Das Stromzeitvolumen ist gemessen am Sauerstoffverbrauch sehr hoch. Während bei anderen Organen die aktuelle Stoffwechsellage und damit der O₂-Verbrauch die lokale Durchblutung bestimmt, bestimmt bei der Niere die aktuelle Durchblutung den Stoffwechsel und damit den O₂-Verbrauch, da ein erhöhter renaler Blutfluss (RBF) und eine in der Regel damit verbundene erhöhte glomeruläre Filtrationsrate (GFR) eine vermehrte tubuläre Resorption erfordern. Trotz hoher Gesamtdurchblutung und niedriger arterio-venöser Differenz des O₂-Gehaltes gibt es Nierenregionen mit sehr niedrigem O₂-Partialdruck (pO₂). Ursache ist die besondere Gefäßarchitektur der Niere, die arterio-venöse O₂-Shuntdiffusionen in der Nierenrinde und im Nierenmark zur Folge hat.

An der Regulation der Nierenhämodynamik sind eine Reihe von Faktoren beteiligt, u.a. Angiotensin II (Ang II), Stickstoffmonoxid (NO) und Adenosin. Die Niere verfügt darüber hinaus über Mechanismen der Autoregulation, d. h. einer relativen Konstanz von RBF und GFR bei Änderung des renalen Perfusionsdruckes (RPP). Dazu gehört der myogene Mechanismus, der tubuloglomeruläre Feedback (TGF), und ein dritter, erst neu entdeckter langsamer Mechanismus (3M), der vermutlich eine metabolische Komponente darstellt. Für TGF und 3M wird postuliert, dass sie vor einem Missverhältnis von Resorptionsnotwendigkeit und niedrigem O₂-Angebot schützen sollen. Prädestiniert für ein solches Missverhältnis ist der dicke aufsteigende Teil der Henleschen Schleife, der bei hohem O₂-Bedarf in einer Region mit niedrigem pO₂ lokalisiert ist. Ein solches Missverhältnis wird als zentrales Element in der Pathogenese verschiedener Nierenerkrankungen wie der akuten prärenalen Niereninsuffizienz, der Röntgenkontrastmittel-induzierten Nephropathie (CIN) und der diabetischen Nephropathie (DNP) angesehen.

Frühere Untersuchungen unserer Arbeitsgruppe befassten sich mit der Regulation und Autoregulation der globalen (renaler Blutfluss) und regionalen (kortikalen und medullären) Hämodynamik und Oxygenierung bei Ratten und Mäusen unter physiologischen Bedingungen. In diesem Rahmen haben wir auch eine Reihe von neuen Methoden für Untersuchungen zur Regulation von renaler Hämodynamik und Oxygenierung in vivo entwickelt bzw. etabliert. Dazu gehören u.a. die kontinuierliche gekoppelte Messung von lokalen Perfusions- und Oxygenierungsgrößen sowie eine Reihe spezifischer Testreize zur quantitativen Bestimmung der Autoregulations-Effizienz und des aktuellen Anteils der drei Autoregulationsmechanismen an der Gesamtregulation.

Mittels dieser standardisierten experimentellen in vivo Techniken untersuchen wir zum einen den Beitrag bestimmter Regulationselemente, z.B. des NO-Systems und des Adenosins, zu Regulation und Autoregulation von renaler Hämodynamik und Oxygenierung unter physiologischen Bedingungen, zum anderen pathophysiologische Mechanismen bestimmter Nierenerkrankungen wie der CIN und der DNP, sowie pharmakologische und prozedurale Möglichkeiten der Prävention bzw. Therapie dieser Erkrankungen.

Unsere Untersuchungen werden durch die Deutsche Forschungsgemeinschaft (Einzelförderungen SE 998/1-1, SE 998/1-3, FL 363/1-1, SE 998/2-1, Forschergruppe FOR 1368, Teilprojekt 3 SE 998/3-2 und Teilprojekt 9 SE 998/4-2), SFB 1365 Projekt B04 sowie durch das Bundesministerium für Bildung und Forschung (Förderprogramm VIP+) und durch industrielle Partner (BayerPharma AG) gefördert.

Cantow K, Gladytz T, Millward JM, Waiczies S, Niendorf T, Seeliger E:
Monitoring kidney size to interpret MRI-based assessment of renal oxygenation in acute pathophysiological scenarios. 
Acta Physiol (Oxf). 2022 Aug 22:e13868. doi: 10.1111/apha.13868. Epub ahead of print

Periquito JS, Gladytz T, Millward JM, Delgado PR, Cantow K, Grosenick D, Hummel L, Anger A, Zhao K, Seeliger E, Pohlmann A, Waiczies S, Niendorf T:
Continuous diffusion spectrum computation for diffusion-weighted magnetic resonance imaging of the kidney tubule system
Quant Imaging Med Surg 11: 3098-3119 (2021)

Zhao K, Pohlmann A, Feng Q, Mei Y, Yang G, Yi P, Feng Q, Chen W, Zhou L, Wu EX, Seeliger E, Niendorf T, Feng Y:
Physiological system analysis of the kidney by high-temporal-resolution T∗2monitoring of an oxygenation step response.
Magn Reson Med. 85:334-345 (2021)

Gladytz T, Millward JM, Cantow K, Hummel L, Zhao KX, Flemming B, Periquito JS, Pohlmann A, Waiczies S, Seeliger E, Niendorf T:
Reliable kidney size determination by magnetic resonance imaging in pathophysiological settings
Acta Physiologica :e13701 (2021)

Pohlmann A, Back SJ, Fekete A, Friedli I, Hectors S, Jerome NP, Ku MC, Longo DL, Meier M, Millward JM, Periquito JS, Seeliger E, Serai SD, Waiczies S, Sourbron S, Laustsen C, Niendorf T:
Recommendation for preclinical renal MRI: A comprehensive open-access protocol collection to improve training, reproducibility, and comparability of studies.
Methods in Molecular Biology 2216:3-23 (2021)

Hosszu A, Kaucsar T, Seeliger E, Fekete A:
Animal Models of Renal Pathophysiology and Disease.
Methods in Molecular Biology 2216:27-44 (2021)

Kaucsar T, Hosszu A, Seeliger E, Reimann HM, Fekete A:
Preparation and monitoring of small animals in renal MRI.
Methods in Molecular Biology 2216:45-55 (2021)

Cantow K, Ladwig-Wiegard M, Flemming B, Fekete A, Hosszu A, Seeliger E:
Reversible (patho)physiologically relevant test interventions: Rationale and examples.
Methods in Molecular Biology 2216:57-73 (2021)

Cantow K, Evans RG, Grosenick D, Gladytz T, Niendorf T, Flemming B, Seeliger E:
Quantitative assessment of renal perfusion and oxygenation by invasive probes: basic concepts.
Methods in Molecular Biology 2216:89-107 (2021)

Li LP, Hack B, Seeliger E, Prasad PV:
MRI mapping of the blood oxygenation sensitive parameter T*₂ in the kidney: Basic concept.
Methods in Molecular Biology 2216:171-185 (2021)

Cantow K, Ladwig-Wiegard M, Flemming B, Pohlmann A, Niendorf T, Seeliger E:
Monitoring renal hemodynamics and oxygenation by invasive probes: Experimental protocols.
Methods in Molecular Biology 2216:327-347 (2021)

Riazy L, Milani B, Periquito JS, Cantow K, Niendorf T, Pruijm M, Seeliger E, Pohlmann A:
Subsegmentation of the kidney in experimental MR images using morphology-based regions-of-interest or multiple-layer concentric objects. Methods in Molecular Biology 2216:549-564 (2021)

Zhao KX, Pohlmann A, Feng QJ, Mei YJ, Yang GX, Yi PW, Feng QJ, Chen WF, Zhou LL, Wu EX, Seeliger E, Niendorf T, Feng YQ: Physiological system analysis of the kidney by high-temporal-resolution T*2 monitoring of an oxygenation step response.
Magn Reson Med 85:334-345 (2021)

Cantow K, Hummel L, Hummel B, Waiczies S, Niendorf T, Seeliger E:
Imagine physiology without imaging.
Acta Physiologica 230:e13549 (2020) 

Niendorf T, Seeliger E, Cantow K, Flemming B, Waiczies S, Pohlmann A:
Probing renal blood volume with magnetic resonance imaging.
Acta Physiol (Oxf). 228:e13435 (2020)
 
Boehmert L, Waiczies H, Kuehne A, Oezerdem C, Waiczies S, Starke L, Ku MC, Pohlmann A, Seeliger E, Niendorf T:
Cardiorenal sodium MRI in small rodents using a quadrature birdcage volume resonator at 9.4 T.
MAGMA. 33:121-130 (2020)
 
Bane O, Mendichovszky IA, Milani B, Dekkers IA, Deux JF, Eckerbom P, Grenier N, Hall ME, Inoue T, Laustsen C, Lerman LO, Liu C, Morrell G, Pedersen M, Pruijm M, Sadowski EA, Seeliger E, Sharma K, Thoeny H, Vermathen P, Wang ZJ, Serafin Z, Zhang JL, Francis ST, Sourbron S, Pohlmann A, Fain SB, Prasad PV:
Consensus-based technical recommendations for clinical translation of renal BOLD MRI.
MAGMA. 33:199-215 (2020)
 
Niendorf T, Frydman L, Neeman M, Seeliger E:
Google maps for tissues: Multiscale imaging of biological systems and disease.
Acta Physiol (Oxf). 228:e13392 (2020)

Beyhoff N, Lohr D, Foryst-Ludwig A, Klopfleisch R, Brix S, Grune J, Thiele A, Erfinanda L, Tabuchi A, Kuebler WM, Pieske B, Schreiber LM, Kintscher U:
Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.
Hypertension. 74:295-304 (2019)

Periquito JDS, Paul K, Huelnhagen T, Ku MC, Ji Y, Cantow K, Gladytz T, Grosenick D, Flemming B, Seeliger E, Waiczies S, Niendorf T, Pohlmann A:
Diffusion-weighted renal MRI at 9.4 Tesla Using RARE to improve anatomical integrity.
Sci Rep 9: 19723 (2019)

Hoff U, Bubalo G, Fechner M, Blum M, Zhu Y, Pohlmann A, Hentschel J, Arakelyan K, Seeliger E, Flemming B, Gürgen D, Rothe M, Niendorf T, Manthati VL, Falck JR, Haase M, Schunck WH, Dragun D:
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.
Acta Physiologica 227:e13297 (2019)

Seeliger E, Persson PB:
Kidney damage by iodinated contrast media.
Acta Physiologica 227:e13259 (2019)

Boehmert L, Kuehne A, Waiczies H, Wenz D, Eigentler TW, Funk S, von Knobelsdorff-Brenkenhoff F, Schulz-Menger J, Nagel AM, Seeliger E, Niendorf T:
Cardiorenal sodium MRI at 7.0 Tesla using a 4/4 chanel 1H/23Na radiofrequency antenna Array.
Magnetic Resonance in Medicine 82: 2343-2356 (2019)

Boyken J, Frenzel T, Lohrke J, Jost G, Schütz G, Pietsch H:
Impact of treatment with chelating agents depends on the stability of administered GBCAs.
Investigative Radiology 54:76-82 (2019)

Cantow K, Flemming B, Ladwig-Wiegard M, Persson PB, Seeliger E:
Publisher correction: Low dose nitrite improves reoxygenation following renal ischemia in rats.
Scientific Reports 8:1748 (2018) 

Boyken J, Niendorf T, Flemming B, Seeliger E:
Gadolinium deposition in the brain after contrast-enhanced MRI: Are the data valid?
Radiology 288: 630-632 (2018)

Boyken J, Frenzel T, Lohrke J, Jost G, Pietsch H:
Gadolinium accumulation in the deep cerebellar nuclei and globus pallidus after exposure to linear but not macrocyclic gadolinium-based contrast agents in a retrospective pig study with high similarity to clinical conditions.
Investigative Radiology 53: 278-285 (2018)

Robert P, Frenzel T, Factor C, Jost G, Rasschaert M, Schuetz G, Fretellier N, Boyken J, Idèe J-M, Pietsch H:
Methodological aspects for preclinical evaluation of gadolinium presence in brain tissue
Critical appraisal and suggestions for harmonization – a joint initiative.
Investigative Radiology 53: 499-517 (2018)

Brix S, Cantow K, Flemming B, Pohlmann A, Niendorf T, Seeliger E.
Interpretation of functional renal MRI findings: Where physiology and imaging sciences need to talk across domains.
J Magn Reson Imaging 47: 1140-1141 (2018)

Grune J, Beyhoff N, Semeir E, Chudek R, Blumrich A, Ban Z, Brix S, Betz IR, Schupp M, Foryst-Ludwig A, Klopfleisch R, Stawowy P, Houtman R, Kolkhof P, Kintscher U:
Selective mineralocorticoid receptor cofactor modulation as molecular basis for finerenone’s antifibrotic activity.
Hypertension 71: 599-609 (2018)

Salatzki J, Foryst-Ludwig A, Bentele K, Blumrich A, Smeir E, Ban Z, Brix S, Grune J, Beyhoff N, Klopfleisch R, Dunst S, Surma MA, Klose C, Rothe M, Heinzel FR, Krannich A, Kershaw EE, Beule D, Schulze PC, Marx N, Kintscher U:
Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure.
PLOS Genetics 14:e1007171 (2018)

Huelnhagen T, Ku M-C, Reimann HM, Duarte TS, Pohlmann A, Flemming B, Seeliger E, Eichhorn C, Ferrari VA, Prothmann M, Schulz-Menger J, Niendorf T:
Myocardial effective transverse relaxation time T2* is elevated in hypertrophic cardiomyopathy: A 7.0 T magnetic resonance imaging study.
Scientific Reports 8: 3974 (2018)

Reimann HM, Todiras M, Hodge R, Huelnhagen T, Millward JM, Turner R, Seeliger E, Bader M, Pohlmann A, Niendorf T.
Somatosensory BOLD fMRI reveals close link between salient blood pressure changes and the murine neuromatrix.
Neuroimage 172: 562-574 (2018)

Wenz D, Kuehne A, Huelnhagen T, Nagel AM, Waiczies H, Weinberger O, Oezerdem C, Stachs O, Langner S, Seeliger E, Flemming B, Hodge R, Niendorf T:
Millimeter spatial resolution in vivo sodium MRI of the human eye at 7 T using a dedicated radiofrequeny transceiver array.
Magnetic Resonance in Medicine 80: 672-684 (2018)

Grune J, Beyhoff N, Smeir E, Chudek R, Blumrich A, Ban Z, Brix S, Betz IR, Schupp M, Foryst-Ludwig A, Klopfleisch R, Stawowy P, Houtman R, Kolkhof P, Kintscher U:
Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone's Antifibrotic Activity.
Hypertension. 71:599-608 (2018)

Grune J, Blumrich A, Brix S, Jeuthe S, Drescher C, Grune T, Foryst-Ludwig A, Messroghli D, Kuebler WM, Ott C, Kintscher U:
Evaluation of a commercial multi-dimensional echocardiography technique for ventricular volumetry in small animals.
Cardiovasc Ultrasound. 16:10 (2018)

Ban Z, Maurischat P, Benz V, Brix S, Sonnenburg A, Schuler G, Klopfleisch R, Rothe M, Gustafsson J-A, Foryst-Ludwig A, Kintscher U:
High-fat diet induces unexpected fatal uterine infections in mice with aP2-Cre-mediated deletion of estrogen receptor alpha.
Scientific Reports 7:43269 (2017)

Pohlmann A, Cantow K, Huelnhagen T, Grosenick D, Santos Periquito dos J, Boehmert L, Gladytz T, Waiczies S, Flemming B, Seeliger E, Niendorf T:
Experimental MRI monitoring of renal blood volume fraction variations en route to renal magnetic resonance oximetry.
Thomography 3: 188-200 (2017)

Cantow K, Flemming B, Ladwig-Wiegard M, Persson PB, Seeliger E:
Low dose nitrite improves reoxygenation following renal ischemia in rats.
Scientific Reports 7: 14597 (2017)

Beyhoff N, Brix S, Betz IR, Klopfleisch R, Foryst-Ludwig A, Krannich A, Stawowy P, Knebel F, Grune J, Kintscher U:
Application of Speckle-Tracking echocardiography in an experimental model of isolated subendocardial damage.
J Am Soc Echocardiogr 30: 1239-1250 (2017)

Huelnhagen T, Hezel F, Serradas Duarte T, Pohlmann A, Oezerdem C, Flemming B, Seeliger E, Prothmann M, Schulz-Menger J, Niendorf T:
Myocardial effective transverse relasation time T2* correlates with left ventricular wall thickness: A 7.0 T MRI study.
Magnetic Resonance Medicine: 77:2381-2389 (2017)

Fähling M, Seeliger E, Patzak A, Persson PB:
Understanding and preventing contrast-induced acute kidney injury.
Nature Reviews Nephrology 13:169-180 (2017)
 
Cantow K, Flemming B, Seeliger E:
Erroneous data on renal hemodynamics derived from DCE-MRI in rats. Letter to the Editor
Journal of Magnetic Resonance Imaging 46:617 (2017) 
 
Lohrke J, Frisk AL, Frenzel T, Schöckel L, Rosenbruch M, Jost G, Lenhard DC, Sieber MA, Nischwitz V, Küppers A, Pietsch H:
Histology and gadolinium distribution in the rodent brain after the administration of cumulative high doses of linear and macrocyclic gadolinium-based contrast agents
Investigative Radiology 52:324-333 (2017) 
 
Jost G, Frenzel T, Lohrke J, Lenhard DC, Naganawa S, Pietsch H:
Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue.
European Radiology 27:2877-2885 (2017) 
 
Niendorf T, Flemming B, Evans RG, Seeliger E:
What do BOLD MR imaging changes in donors' remaining kidneys tell us? Letter to the Editor
Radiology 281:653-654 (2016)

Cantow K, Pohlmann A, Flemming B, Ferrara F, Waiczies S, Grosenick D, Niendorf T, Seeliger E:
Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation.
Scientific Reports 6: 29965 (2016)

Jost G, Lenhard DC, Sieber MA, Lohrke J, Frenzel T, Pietsch H:
Signal increase on unenhanced T1-weighted images in the rat brain after repeated, extended doses of gadolinium-based contrast agents: Comparison of linear and macrocyclic agents.
Investigative Radiology 51(2): 83-9 (2016)

Cantow K, Arakelyan K, Seeliger E, Niendorf T, Pohlmann A:
Assessment of Renal Hemodynamics and Oxygenation by Simultaneous Magnetic Resonance Imaging (MRI) and Quantitative Invasive Physiological Measurements.
Methods in Molecular Biology 1397:129-54 (2016)

Pohlmann A, Arakelyan K, Seeliger E, Niendorf T:
Magnetic Resonance Imaging (MRI) Analysis of Ischemia/Reperfusion in Experimental Acute Renal Injury.
Methods in Molecular Biology 1397:113-27 (2016)

Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ, Jahn R:
The GTPase Rab26 links synaptic vesicles to the autophagy pathway. 
eLife 4: e05597 (2015)

Grosenick D, Cantow K, Arakelyan K, Wabnitz H, Flemming B, Skalweit A, Ladwig M, Macdonald R, Niendorf T, Seeliger E:
Monitoring hemodynamics and oxygenation of the kidney in rats by a combined near-infrared spectroscopy and invasive probe approach.
Proc Spie 9538 Diffuse Optical Imaging V, 95380L (2015)

Grosenick D, Wabnitz H, Macdonald R, Niendorf T, Cantow K, Flemming B, Arakelyan K, Seeliger E:
Characterization of hemodynamics and oxygenation in the renal cortex of rats
Proceedings of SPIE 9319: 93191C-1 (2015)

Niendorf T, Pohlmann A, Reimann HM, Waiczies H, Peper E, Huelnhagen T, Seeliger E, Schreiber A, Kettritz R, Strobel K, Ku MC, Waiczies S:
Advancing cardiovascular, neurovascular, and renal magnetic resonance imaging in small rodents using cryogenic radiofrequency coil technology
Frontiers in Pharmacology 6: 255 (2015)

Ladwig M, Cantow K, Flemming B, Persson PB, Seeliger E:
Comparison of the effects of iodixanol and iopamidol on urine flow, urine viscosity, and glomerular filtration in rats
Journal of Urology and Nephrology 2 (1): 7 (2015)
 
Grosenick D, Cantow K, Arakelyan K, Wabnitz H, Flemming B, Skalweit A, Ladwig M, Macdonald R, Niendorf T, Seeliger E:
Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach.
Biomedical Optics Express 6: 309-323 (2015)
 
Niendorf T, Pohlmann A, Arakelyan K, Flemming B, Cantow K, Hentschel J, Grosenick D, Ladwig M, Reimann H, Klix S, Waiczies S, Seeliger E:
How bold is blood oxygenation level-dependent (BOLD) magnetic resonance imaging of the kidney? Opportunities, challenges and future directions.
Acta Physiologica 213: 19-38 (2015)

Lenhard DC, May E, Morgenroth C, Jost G, Haider W, Pietsch H:
Adverse skin reactions to iodinated x-ray contrast agents in healthy rats.
Investigative Radiology 49(12): 779-87 (2014)

Pohlmann A, Arakelyan K, Hentschel J, Cantow K, Flemming B, Ladwig M, Waiczies S, Seeliger E, Niendorf T:
Detailing the relation between renal T2* and renal tissue pO2 using an integrated approach of parametric magnetic resonance imaging and invasive physiological measurements.
Investigative Radiology 49: 547-560 (2014)

Liu Z, Schmerbach K, Lu Y, Perlewitz A, Nikitina T, Cantow K, Seeliger E, Persson PB, Patzak A, Liu R, Sendeski M:
Iodinated contrast media cause direct tubular cell damage, leading to oxidative stress, low nitric oxide, and impairment of tubulo-glomerular feedback.
American Journal of Physiology, Renal Physiology 306: F864-F872 (2014)

Seeliger E, Lenhard DC, Persson PB:
Contrast media viscosity versus osmolality in kidney injury: lessons from animal studies.
Biomed Research International 2014: 358136 (2014)

Seeliger E, Cantow K, Arakelyan K, Ladwig M, Persson PB, Flemming B:
Low-dose nitrite alleviates early effects of an x-ray contrast medium on renal hemodynamics and oxygenation in rats.
Investigative Radiology 49: 70-77 (2014)
 
Arakelyan K, Cantow K, Hentschel J, Flemming B, Pohlmann A, Ladwig M, Niendorf T, Seeliger E:
Early effects of an x-ray contrast medium on renal T2*/T2 MRI as compared to short-term hyperoxia, hypoxia and aortic occlusion in rats.
Acta Physiologica 208: 202-213 (2013) 

Pohlmann A, Hentschel J, Fechner M, Hoff U, Bubalo G, Arakelyan K, Cantow K, Seeliger E, Flemming B, Waiczies H, Waiczies S, Schunck WH, Dragun D, Niendorf T:
High temporal resolution parametric MRI monitoring of the initial ischemia/reperfusion phase in experimental acute kidney injury.
PLoS ONE 8: e57411 (2013) 

Grosenick D, Steinkellner O, Wabnitz H, Macdonald R, Niendorf T, Cantow K, Flemming B, Seeliger E:
Near-infrared spectroscopy of renal tissue in vivo.
Proceeding of SPIE 8578: 85781P-1 (2013)

Pohlmann A, Cantow K, Hentschel J, Arakelyan K,Ladwig M, Flemming B, Hoff U, Persson PB, Seeliger E, Niendorf T:
Linking non-invasive parametric MRI with invasive physiological measurements (MR-PHYSIOL): towards a hybrid and integrated approach for investigation of acute kidney injury in rats.
Acta Physiologica 207: 673-689 (2013)

Andreas K, Georgieva R, Ladwig M, Mueller S, Notter M, Sittinger M, Ringe J: Highly efficient magnetic stem cell labeling with citrate-coated supermagnetic iron oxide nanoparticles for MRI tracking.
Biomaterials 33: 4515-4525 (2012) 

Seeliger E, Ladwig M, Sargsyan L, Cantow K, Persson PB, Flemming B:
Proof of Principle: Hydration by Low-osmolar Mannitol-Glucose Solution Alleviates Undesirable Renal Effects of an Iso-osmolar Contrast Medium in Rats.
Investigative Radiology 47: 240-246 (2012)

Seeliger E, Sendeski M, Rihal CS, Persson PB:
Contrast-induced kidney injury: mechanisms, risk factors, and prevention.
European Heart Journal 33: 2007-2015 (2012)

Haase M, Bellomo R, Story D, Letis A, Klemz K, Matalanis G, Seevanayagam S, Dragun D, Seeliger E, Mertens PR, Haase-Fielitz A
Effect of mean arterial pressure, haemoglobin and blood transfusion during cardiopulmonary bypass on post-operative acute kidney injury.
Nephrol Dial Transplant 27: 153-160 (2012)

Ladwig M, Flemming B, Seeliger E, Sargsyan L, Persson PB
Renal effects of bicarbonate vs. saline infusion for Iso- and Low-osmolar contrast media in rats.
Invest Radiol 46: 672-677 (2011)

Hoff U, Lukitsch I, Chaykovska L, Ladwig M, Arnold C, Manthati VL, Fuller TF, Schneider W, Gollasch M, Müller DN, Flemming B, Seeliger E, Luft FC, Falck JR, Dragun D, Schunck WH
Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury.
Kidney Intern. 79: 57-65 (2011)

Seeliger E, Becker K, Ladwig M, Wronski T, Persson PB, Flemming B
Up to 50-fold increase in urine viscosity with iso-osmolar contrast media in the rat.
Radiology 256: 406-414 (2010)

Seeliger E, Lunenburg T, Ladwig M, Reinhardt HW
Role of the renin-angiotensin-aldosterone system for control of arterial blood pressure following moderate deficit in total body sodium: Balance studies in freely mowing dogs.
Clinical Experimental Pharmacol. Physiol. 37: e43-e51 (2010)

Seeliger E, Wronski T, Ladwig M, Dobrowolski L, Vogel T, Godes M, Persson PB, & Flemming B
The renin-angiotensin system and the third mechanism of renal blood flow autoregulation.
Am. J. Physiol. Renal Physiol. 296: F1334-F1345 (2009)

Patzak A, Steege A, Lai EY, Brinkmann JO, Kupsch E, Spielmann N, Gericke A, Skalweit A, Stegbauer J, Persson PB, & Seeliger E
Angiotensin II response in afferent arterioles of mice lacking either the endothelial or neuronal isoform of nitric oxide synthase.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 294: R429-R437 (2008)

Seeliger E, Flemming B, Wronski T, Ladwig M, Arakelyan K, Godes M, Möckel M & Persson PB
Viscosity of contrast media perturbs renal hemodynamics.
J. Am. Soc. Nephrol. 18: 2912-2920 (2007)