Research at the Institute of Vegetative Physiology

The basic research of the Institute of Vegetative Physiology at the Charité – Universitätsmedizin Berlin is especially the kidney function and their importance for the blood flow. Additionally, we focus on several aspects of developmental physiology.

Please inform you about the current research and several publications of the four labs on the following pages.

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The main research topics of the four labs

Integrative Kidney Physiology Lab

  • Regulation and autoregulation of the renal blood flow and oxygenation
  • Pathophysiological mechanisms and prevention of contrast induced nephropathy
  • Pathophysiological mechanisms and prevention of diabetic nephropathy

Molecular Physiology Lab

  • Research of adaptation to hypoxia at the cellular and organ-specific level
  • Mechanisms up- and downstream of hypoxia-inducible factor in acute kidney injury
  • Prevention of Cyclosporin-A mediated nephrotoxicity
  • Posttranscriptional control of the bHLH transcription factor hASH1/Mash1
  • Cellular adaptation to hypoxia: role of mRNA translation

Physiology of the Vessels Lab

  • Illumination of the function of kidney and brain vessels
  • Role of endocrine, autocrine and paracrine substance on the Regulation of renal arteries and microvessels
  • Importance of the vascular component during the development of acute kidney injury and the pathogenesis of cerebral vasospasmus

Developmental Cellular Physiology and Pathophysiology Lab

  • Function of the Wilms tumor protein WT1 in embryonic development and disease
  • Molecular mechanisms of oxygen-dependent gene expression
  • Developmental erythropoietin production in liver and kidney
  • Role of polyamines in acute and chronic kidney injury

Detailed publication list



Overview of the supported projects

German Research Foundation

Project "Molecular mechanisms of adaptation to intrauterine and perinatal changes of oxygen partial pressure: The liver-to-kidney switch of Erythropoietin production as model System" KI 1441/4, 2017-2020

Project "Regulation of renal perfusion and oxygenation in sepsis-induced acute kidney injury" FOR 1368 TP3 AR 947/1, 2014 - 2017

Project "Hypoxia and vasa recta function" FOR 1368 TP2 SE 1948/3, 2014 - 2017

Project "Hypoxia and vasa recta function" FOR 1368 TP2 PE 388/23, 2014 - 2017

Project "Hypoxia and vasa recta function" FOR 1368 TP2 PA 479/10, 2014 - 2017

Project "Regulation of renal perfusion and oxygenation in sepsis-induced acute kidney injury" FOR 1368 TP3 SE 998/3, 2014 - 2017

Project "Mechanisms up- and downstream of hypoxia-inducible factor in acute kidney injury" FOR 1368 TP8 FA 845/4, 2014 - 2017

Project Research Group FOR 1368 "Hemodynamic mechanisms of acute kidney infury" TPZ1 PE 388/22, 2014 - 2017

Project Research Group FOR 1368 "Hemodynamic mechanisms of acute kidney injury" TPZ1 PE 388/22, 2011 - 2015

Project "Contrast media and juxtaglomerular apparatus function" FOR 1368 TP2 PA 479/10, 2011 - 2014

Project "Acute kidney injury, renal hemodynamics and potential benefit of nitrite" FOR 1368 TP3 SE 998/3, 2011 - 2014

Project "Regulation and synergism of transcription factors Wt1 and Gata 4 in the heart and gonads" SCHO 634/8, 2011 - 2013

Project "Direct effects of Glucagon-like peptide 1 on renal hemodynamics and oxygenation" SE 998/2, 2009-2014

Project "Posttranscriptional control of bHLH transcription factor Mash1 gene expression rate" FA 845/2, 2008-2014

Project "Mechanisms and consequences of an oxygen-dependent expression of the TrkB neurotrophin receptor" SCHO 634/6, 2007 - 2010

Project "Posttranscriptional control of Na-Channel-Protein ENaC synthesis" TH 459/5, 2006 – 2008

Project "Genetic eNOS background and fetal programming" PE 388/20, 2005 – 2007

Project "Regulation of the erythropoietin and its receptor gene by the Wilmstumor transcription factor Wt1: Significance for hematopoieses" Prof. Dr. Scholz in co-operation with Prof. Dr. Dame (Clinic for Neonatology, Charité CVK/CBF), 2005 – 2007

Project "Wt1 expression in the myocardioal vasculature: Mechanisms and consequences" SCHO 634/5, 2003 – 2006

Project "Sodium balance and blood pressure" RE 491/5, 2002 – 2006

Project "Identification of downstream target genes of the Wilms tumor transcription factor Wt1" SCHO 634/4, 2002 – 2005

Project: "Posttranskriptional control of the gene expression in heart muscle at Myokardhypertrophie" Project: "Blood pressure variability and heart hypertrophy", 2001 – 2010

Project "Sodium balance and blood pressure I" SE 998/1, 2000 – 2006

Project "Translational regulation of renin synthesis" PE 388/16, 2000 – 2005

Industry/Foundation

Scholarship, M. Ludwig, Lydia Rabinowitsch, 2017-2018

Scholarship, D. Braun, Sonnenfeld-Stiftung, 2017

Project "Wilms tumor protein Wt1 and diabetes mellitus" Else Kröner-Fresenius-Stiftung, Project leader: Prof. Dr. Holger Scholz, 2014-2017

Project "Renal safety of contrast media: Pharmaceuticals, mechanisms and prevention strategies", Bayer Pharma AG, Project leader: Prof. Dr. Pontus B. Persson, Dr. Erdmann Seeliger, 2013-2016

Project "Regulation and function of the metalloproteinase ADAMTS 16" Sonnenfeldstiftung, Project leader: Prof. Dr. Holger Scholz, 2010 - 2011

Project "Renal safety of contrast media: Mechanisms and prevention strategies", Bayer Schering Pharma AG, Project leader: Prof. Dr. Pontus B. Persson, Dr. Erdmann Seeliger, 2010-2012

Project "Contrast media and oxidative stress in the renal medulla" Else Kroener-Fresenius-Stiftung, Project leader: Prof. Dr. Andreas Patzak, 2009-2012

Scholarship ZZ Liu Research Ministery China; 2009-2013

Scholarship I. Moraes da Silva German Academic Exchange Service (DAAD); 2009

Project "Contrast-media induced nephropathy: Role of physico-chemical properties of contrast media", Bayer Schering Pharma AG, Projeckt leader: Prof. Dr. Pontus B. Persson, OA Dr. Bert Flemming, Dr. Erdmann Seeliger, 2008-2010

Project "Cis-regulatory interaction", Sonnenfeldstiftung, Project leader: PD Dr. Ralf Mrowka, 2008-2011

Project "Hämodynamische Effekte der Kontrastmittel Iopromide und Iodixanol auf die Niere", Bayer Schering Pharma, Project leader: Prof. Dr. P. B. Persson; 2008-2010

Project "Kontrastmittel-induzierte Nephropathie: Modulation akuter Effekte von Iodixanol durch den Adenosin A1-Agonisten BR-4461", Bayer Schering Pharma, Project leader: Prof. Dr. P. B. Persson, Dr. E. Seeliger ; 2007-2009 

Scholarship M. Sendeski Werner-Jackstaedt-Stiftung; 2007-2008

Project "Development and validation of an MRT-Method for quantification of the local intrarenal blood circulation", Bayer Schering Pharma, Project leader: PD Dr. B. Nafz, Dr. Lüdemann, Dr. Lengsfeld, Dr. Voth, seit 2006

Project "Contrast medium induced nephropathy: Iopromide 370, Iodixanol, Iopromide 370 and osmotic diuresis", Bayer Schering Pharma, Project leader: Prof. Dr. P. B. Persson, 2006-2010

Project "Contrast medium induced nephropathy: Prevention of acute effects of Iodixanol by SLV320", Solvay Pharmaceuticals,  Project leader: Prof. Dr. Persson, 2006 – 2010

Project "Contrast medium induced nephropathy", Schering AG, Project leader: Prof. Persson, 2005 – 2006

Project "Non-linear dynamic of the peripheral circulation", Friedrich-Schiller-University Jena, Project leader: PD Dr. Ralf Mrowka, 1999 – 2006